The lab investigates the molecular mechanisms of metabolic disease, with a focus on how protein palmitoylation regulates fatty acid uptake and how transcriptional regulators determine adipocyte fate.
Two related questions in lipid metabolism: how DHHC enzymes attach fatty acids to substrate proteins, and how transcriptional regulators commit precursor cells to specific adipocyte fates.
We map how DHHC family enzymes attach long-chain fatty acids to specific cysteines, and how that single chemical event rewrites metabolic signaling, organelle targeting, and insulin response in vivo.
We identify and characterize transcription factors and epigenetic regulators that decide whether a precursor commits to beige, white, or brown adipose, with the long-term goal of redirecting fat storage in disease.
Professor
Institute of Metabolism and Integrative Biology
Fudan University
The laboratory studies the physiology and molecular mechanisms of metabolic diseases, with current work focused on tissue-specific fatty acid uptake, storage, and utilization.
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